These patches plump up your fine lines instantly, especially around your eyes and lips. The patches are all natural and you will see results after the first thirty-minute treatment. The anti-wrinkle benefits of one application last approximately 12 hours. Benefits are cumulative. For optimal results, we recommend 6 treatments, one every other day, for 12 days, which results in a 39% cell renewal. Recommended follow-up is 3 treatments monthly. Six patches included.